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PhD National Taiwan University 1998
Associate Professor

Department of Bioinformatics and Medical Engineering
Asia University
500, Lioufeng Rd., Wufeng, Taichung 41354, Taiwan
Tel: +886-(4)-2332-3456
Email: peichun.chang@gmail.com
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Pei-Chun Chang received his Ph.D. degree in Chemistry from the National Taiwan University, Taiwan in 1998. Currently, Pei-Chun Chang is an associate professor with the Department of Bioinformatics and Medical Engineering at Asia University where he is conducting research activities in the areas of biomedical informatics and computing chemistry. His research interests concern the discovery of cancer biomarkers by genomics analysis, the screening of anticancer compounds from Chinese herb components, the development of disease model with systems biology, and medical data mining.

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  1. Chun-Chi Liu, Chin-Chung Lin, Wen-Shyen E. Chen, Hsuan-Yu Chen, Pei-Chun Chang, Jeremy J.W. Chen, and Pan-Chyr Yang (2006) CRSD: a comprehensive web server for composite regulatory signature discovery. Nucleic Acids Research., 34. W571-W577. (SCI)
  2. Chun-Chi Liu, Wen-Shyen E. Chen, Chin-Chung Lin, Hsiang-Chuan Liu, Pan-Chyr Yang, Pei-Chun Chang*, and Jeremy J.W. Chen* (2006) Topology-based cancer classification and related pathway mining using microarray data. Nucleic Acids Research., 34, p4069-p4080. (SCI)
  3. Chun-Chi Liu, Chin-Chung Lin, Ker-Chau Li, Wen-Shyen E. Chen, Jiun-Ching Chen, Ming-Te Yang, Pan-Chyr Yang, Pei-Chun Chang*, Jeremy J.W. Chen* (2007) Genome-wide identification of specific oligonucleotides using artificial neural network and computational genomic analysis. BMC Bioinformatics., 8, p164. (SCI)
  4. Hsiang-Chuan Liu, Shin-Wu Liu, Pei-Chun Chang, Wen-Chun Huang, and Chien-Hsiung Liao* (2008) A novel classifier for influenz A viruses based on svm and logistic regression. The International Conference on Wavelet Analysis and Pattern Recognition (ICWAPR) 2008. p287-p291 (Conference EI)
  5. Jiunn-I Shieh, Kuei-Jen Lee, Jing-Doo Wang, Chung-Hung Li, Am-Chou Chen, Pei-Chun Chang*, and Hsiang-Chuan Liu (2008) Physiochemical constraints in influenza A hemagglutinin. The 4rd International Conference on Natural Computation (ICNC'08). p85-p89 (Conference EI)
  6. Han-Wen Hsiao*, Shih-Hao Chen, Pei-Chun Chang, and Jeffery J.P. Tsai (2008) Predicting subcellular locations of eukaryotic proteins using bayesian and k-nearest neighbor classifiers. Journal of Information Science and Engineering, 24, p 1361-p1375. (SCI)
  7. Jiunn-I Shieh, Yu-Lung Liu, Kuei-Jen Lee, Pei-Chun Chang, Yi-Cheng Liu (2009) A novel predicting algorithm of thermostable proteins based on choquet integral with respect to l-measure and hurst exponent. Proceedings of the Eighth International Conference on Machine Learning and Cybernetics. p3167-p3171. (EI)
  8. Ta-Cheng Chen, Jiunn-I Shieh, Kuei-Jen Lee, Jing-Doo Wang, Pei-Chun Chang*, Hsiang-Chuan Liu (2009) Nonlinear dynamic indications in time Series of epilepsy electroencephalogram. The Ninth IEEE International Conference on Bioinformatics and Bioengineering. (Conference EI)
  9. Horng-Jinh Chang, Pei-Chun Chang, Hsiang-Chuan Liu, Kuei-Jen Lee, Jing-Doo Wang, Yu-Lung Liu (2010) Choquet integral algorithm for thermostable proteins based on Hurst exponent and generalized L-measure. Proceedings of the ninth International Conference on Machine Learning and Cybernetics. P2383-p2389. (EI)
  10. Po-Fon Chen, Ya-Li Hsiao, Hsiang-Chuan Liu and Pei-Chun Chang* (2011) Theoretical Assessment of Immunogenicity Variation on The HA protein of H2N2 influenza virus by using fuzzy integral and SVM classifier. Proceedings of 2011 International Conference on Machine Learning and Cybernetics. P799-p803. (EI)
  11. Ya-Li Hsiao, Po-Feng Chen, Hsiang-Chuan Liu, Pei-Chun Chang* (2011) Choquet integral algorithm for T-cell epitope prediction based on fuzzy measure. The 8th International Conference on Fuzzy Systems and Knowledge Discovery. (Conference EI)
  12. Pei-Chun Chang, Yi Chen, Ming-Tsong Lai, Heng-Yuan Chang, Chung-Ming Huang, Hsin-Ping Liu, Wei-Yong Lin, Chin-Ho Lai, Jim Jinn-Chyuan Sheu, and Fuu-Jen Tsai (2011) Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in taiwan chinese han population. The Journal of Rheumatology. 38, p2376-p2381. (SCI)
  13. Pei-Chun Chang, Jing-Doo Wang, Min-Min Lee, Su-Sen Chang, Tsung-Ying Tsai, Kai-Wei Chang, Fuu-Jen Tsai, and Calvin Yu-Chian Chen (2011) Lose weight with traditional chinese medicine? potential suppression of fat mass and obesity-associated protein. Journal of Biomolecular Structure and Dynamics. 29, p424-p596. (SCI)
  14. Hung IC., Chang SS, Chang PC, Lee CC, Chen CY. (2013) Memory-Enhancement by Traditional Chinese Medicine? Journal of Biomolecular Structure and Dynamics. 31, p1411-p1439. (SCI)
  15. Jia-Zhen Guo, Yo-Xiu Lin, Pei-Chun Chang, Chieh-Hsi Wu, Phillip C. Y. Sheu, Jeffrey J. P. Tsai (2014) Compounds screening from traditional Chinese herbs for inhibition of in-stent restenosis in coronary atherosclerosis. The Twelfth Asia-Pacific Bioinformatics Conference (APBC2014)
  16. Wang CC, Chang PC, Ng KL, Chang CM, Sheu PC, Tsai JJ. (2014) A model comparison study of the flowering time regulatory network in Arabidopsis. BMC Systems Biology. 8, PMID: 24513114
  17. Huang BR, Chang PC, Yeh WL, Lee CH, Tsai CF, Lin C, Lin HY, Liu YS, Wu CY, Ko PY, Huang SS, Hsu HC, Lu DY (2014) Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications for neuroprotection. PLoS One. 12, e91167.
  18. Chuang JY, Chang PC, Shen YC, Lin C, Tsai CF, Chen JH, Yeh WL, Wu LH, Lin HY, Liu YS, Lu DY. (2014) Regulatory effects of fisetin on microglial activation. Molecules. 19, 8820-8839. (SCI)
  19. Ya-Li Hsiao, Pei-Chun Chang,  Hung-Jin Huang, Chia-Chen Kuo, and Calvin Yu-Chian Chen (2014) Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine. PMID: 25136372
  20. Wu LH, Lin C, Lin HY, Liu YS, Wu CY, Tsai CF, Chang PC, Yeh  WL, Lu DY (2015) Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression. Mol Neurobiol. PMID: 25579382
  21. Lin HY, Tsai CH, Lin C, Yeh WL, Tsai CF, Chang PC, Wu LH, Lu DY. (2016) Cobalt Protoporphyrin Upregulates Cyclooxygenase-2 Expression Through a Heme Oxygenase-Independent Mechanism. Mol Neurobiol. 53, 4497-508. (SCI)
  22. Tang HC, Chang PC, Chen YC. (2016) Iron depletion strategy for targeted cancer therapy: utilizing the dual roles of neutrophil gelatinase-associated lipocalin protein. J Mol Model., 22, 32.
  23. Chen KB, Chen KC, Chang YL, Chang KL, Chang PC, Chang TT, Chen YC. (2016) In Silico Investigation of Traditional Chinese Medicine for Potential Lead Compounds as SPG7 Inhibitors against Coronary Artery Disease. Molecules., 21, E588.
  24. Chang YL, Chen HY, Chen KB, Chen KC, Chang KL, Chang PC, Chang TT, Chen YC. (2016) Investigation of the inhibitors of histone-lysine N-methyltransferase SETD2 for acute lymphoblastic leukaemia from traditional Chinese medicine. SAR QSAR Environ Res., 27, 589-608.
  25. Chen JH, Tsai CH, Lin HY, Huang CF, Leung YM, Lai SW, Tsai CF, Chang PC, Lu DY, Lin C. (2016) Interlukin-18 Is a Pivot Regulatory Factor on Matrix Metalloproteinase-13 Expression and Brain Astrocytic Migration. Mol Neurobiol., 53, 6218-6227.
  26. Huang BR, Chen TS, Bau DT, Chuang IC, Tsai CF, Chang PC, Lu DY. (2017) EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture. Scientific Reports., 7, 8578.
  27. Tsai CF, Cheng YK, Lu DY, Wang SL, Chang CN, Chang PC, Yeh WL. (2017) Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers. Toxicol Appl Pharmacol., 338, 182-190.

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